Home » 2015 » March

Monthly Archives: March 2015

Viagra and liquor

Savoring liquor balance is by all accounts safe when you take Viagra. There is by all accounts no reasonable sign that the dangers of liquor utilize are exacerbated by Viagra. A review distributed in Clinical Pharmacology and Therapeutics found no unfavorable responses amongst Viagra and red wine. Be that as it may, examine on this point is constrained.

Still, since Viagra and liquor don’t appear to collaborate doesn’t imply that it’s a smart thought to utilize them together. This is on the grounds that constant liquor utilize is a typical reason for ED. It’s so normal, truth be told, that a slang term for ED in Great Britain is “brewer’s hang.” So while you’re treating ED with Viagra, you might do yourself an insult by blending the medication with liquor.

Perused more: 5 basic reasons for ED, in addition to treatment and counteractive action tips »

Liquor and ED

Liquor and Pills

Researchers at Loyola University looked into 25 years of research on the impacts of liquor use on the male regenerative framework. Here are some of their discoveries. These impacts need to do with liquor as a rule and are not particular to consolidating Viagra with liquor. Still, on the off chance that you have erectile brokenness, you might need to consider how liquor can impact your sexual wellbeing and execution.

Impacts on testosterone and estrogen

Both hitting the bottle hard and ceaseless liquor utilize can influence testosterone and estrogen levels.

Testosterone in men is made in the testicles. It assumes a part in many elements of the body. It’s additionally the hormone most firmly connected to male sexuality, and it’s in charge of the improvement of sexual organs and sperm.

Estrogen is predominantly a female hormone, but at the same time it’s found in men. It’s connected with the improvement of female sexual qualities and multiplication.

In case you’re a man, expending more than a direct measure of liquor may bring down your testosterone levels and raise your estrogen levels. Decreased testosterone levels joined with more elevated amounts of estrogen may feminize your body. Your bosoms may develop or you may lose body hair.

Consequences for the balls

Liquor is poisonous to balls. Sources say expending a considerable measure of liquor after some time can bring about shrinkage in your balls. This decreases the volume and nature of your sperm.

Impacts on the prostate

As indicated by a few sources, liquor mishandle might be related with prostatitis (irritation of the prostate organ). Side effects may incorporate swelling, agony, and issues with pee. Prostatitis may likewise be connected with erectile brokenness.

Reasons for erectile brokenness

men

To comprehend why ED happens, it knows how an erection happens. An erection really begins in your mind. When you get to be distinctly stimulated, motions in your mind go to different parts of your body. Your heart rate and blood stream increment. Chemicals are set off that make blood stream into empty chambers in your penis. This causes an erection.

In ED, nonetheless, a catalyst called protein phosphodiesterase sort 5 (PDE5) meddles with this procedure. Thus, there’s not an expansion in blood stream to the supply routes in your penis. This prevents you from getting an erection.

These addicted people are at the manner to the constant and positive death

These addicted people are at the manner to the constant and positive death. It is a social evil that influences the person in addition to the state as an entire.

Causes

It is suspected that there’s an underneath band to decrease and to destroy the youths of our united states and to make our state physically, intellectually and morally weak and invalid for all time.

Various kinds of capsules come to the market through the smugglers and dishonest buyers and peddlers. At first the students and youths take it out of interest or to fly to the dream-land of intoxication.

Effects

The habit of Drug Addiction step by step takes over them and they are able to by no means shake-off this addiction.

The effect of those risky pills could be very deadly and horrible. It spoils the stomachs, effects the nerves and disturbs the chemical balance of the frame of the addicts they experience vulnerable and shaky.

Solution

According to an estimate, there are approximately lakhs of drug addicts in huge towns inclusive of Mumbai, Delhi, Kolkata and Bangalore.

A survey many of the University college students suggests that many students are addicted to this drug or that drug. Thus we discover that scenario involves a crucial role and the preventive measures ought to now not be delayed any extra.

So, a fashionable awareness should be awakening inside the government, the guardians and the youths to fight off the evils collectively.

Many human beings do not understand why or how different human beings become addicted to tablets. They can also mistakenly think that folks who use drugs lack ethical concepts or strength of will and that they could forestall their drug use sincerely by using choosing to. In truth, drug addiction is a complicated sickness, and quitting normally takes greater than desirable intentions or a strong will. Drugs alternate the brain in ways that make quitting tough, even for individuals who need to. Fortunately, researchers recognise extra than ever approximately how capsules have an effect on the brain and feature determined treatments that can help humans recover from drug dependancy and lead productive lives.

According to the Africa Economic Institute

According to the Africa Economic Institute, the value of illicit drug smuggling in Guinea-Bissau is almost twice the value of the country’s GDP.[34] Police officers are often bribed. A police officer’s normal monthly wage of $93 is less than 2% of the value of 1 kilogram (2.2 lb) of cocaine (€7000 or $8751).[citation needed] The money can also be laundered using real estate. A house is built using illegal funds, and when the house is sold, legal money is earned.[35] When drugs are sent over land, through the Sahara, the drug traders have been forced to cooperate with terrorist organizations, such as Al Qaida in Islamic Maghreb
Statistics about profits from the drug trade are largely unknown due to its illicit nature. In its 1997 World Drugs Report the United Nations Office on Drugs and Crime estimated the value of the market at $4 trillion, ranking drugs alongside arms and oil among the world’s largest traded goods.[40] An online report published by the UK Home Office in 2007 estimated the illicit drug market in the UK at £4–6.6 billion a year[41]

In December 2009 United Nations Office on Drugs and Crime Executive Director Antonio Maria Costa claimed illegal drug money saved the banking industry from collapse. He claimed he had seen evidence that the proceeds of organized crime were “the only liquid investment capital” available to some banks on the brink of collapse during 2008. He said that a majority of the $352 billion (£216bn) of drug profits was absorbed into the economic system as a result:

“In many instances, the money from drugs was the only liquid investment capital. In the second half of 2008, liquidity was the banking system’s main problem and hence liquid capital became an important factor…Inter-bank loans were funded by money that originated from the drugs trade and other illegal activities…there were signs that some banks were rescued that way”.[42]

Business Market Management: Understanding, Creating, and Delivering Value

Anderson, James C., and Narus, James A. (2004) Business Market Management: Understanding, Creating, and Delivering Value, 2nd Edition, 2004, Pearson Education, Inc. ISBN 978-0131408418
Business Marketing Association (2003) “Marketing Reality Survey”
Blaney, Bill (2012) B2B A To Z. Marketing Tools and Strategies That Generate Leads For Business-To-Business Companies, Denham Publishing , 2012. p. 8-12 ISBN 978-0988497702
Dwyer, F. Robert, Tanner, John F. (2006). Business Marketing: Connecting Strategy, Relationships, and Learning (3rd ed.). McGraw-Hill/Irwin. ISBN 978-0073529905.
Greco, John A. Jr., (June 13, 2005). “Past indicates promising future for b-to-b direct”. BtoB magazine.
Hutt, Michael D., Speh, Thomas W. (2004). Business Marketing Management: A Strategic View of Industrial and Organizational Markets (8th ed.). Thomson/South-Western. ISBN 978-0324190434.
Morris, Michael H., Pitt, Leyland F., and Honeycutt, Earl Dwight (2001) Business-to-Business Marketing: A Strategic Approach, Sage Publications Inc.
Reid, David A.; Plank, Richard E. (2004). Fundamentals of Business Marketing Research. Best Business Books, an Imprint of The Haworth Press, Inc. ISBN 978-0789023117.
Brown, Duncan and Hayes, Nick. Influencer Marketing: Who really influences your customers?, Butterworth-Heinemann, 2008
John Fahy and David Jobber, Foundations of marketing, Rogan (2011: p137)

According to Anderson and Narus

According to Anderson and Narus (2004), two new types of resellers have emerged as by-products of the Internet: infomediaries and metamediaries. Infomediaries, such as Google and Yahoo, are search engine companies that also function as brokers, or middlemen, in the business marketing world. They charge companies fees to find information on the Web as well as for banner and pop-up ads and search engine optimization services. Metamediaries are companies with robust Internet sites that furnish customers with multiproduct, multivendor and multiservice marketspace in return for commissions on sales.

With the advent of b-to-b exchanges, the Internet ushered in an enthusiasm for collaboration that never existed before—and in fact might have even seemed ludicrous 10 years ago. For example, a decade ago who would have imagined Ford, General Motors and DaimlerChrysler entering into a joint venture? That’s exactly what happened after all three of the Big Three began moving their purchases online in the late 1990s. All three companies were pursuing their own initiatives when they realized the economies of scale they could achieve by pooling their efforts. Thus was born what then was the world’s largest Internet business when Ford’s Auto-Xchange and GM’s TradeXchange merged, with DaimlerChrysler representing the third partner.

While this exchange did not stand the test of time, others have, including Agentrics, which was formed in 2005 with the merger of WorldWide Retail Exchange and GlobalNetXchange, or GNX. Agentrics serves more 50 retailers around the world and more than 300 customers, and its members have combined sales of about $1 trillion. Hutt and Speh (2001) note that such virtual marketplaces enable companies and their suppliers to conduct business in real time as well as simplify purchase processes and cut costs.
References

Impact of the Internet

Technological revolution. Technology is changing at an unprecedented pace, and these changes are speeding up the pace of new product and service development. A large part of that has to do with the Internet, which is discussed in more detail below. Technology and business strategy go hand in hand. Both are correlated. While technology supports forming organization strategy, the business strategy is also helpful in technology development. Both play a role in business marketing.
Entrepreneurial revolution. To stay competitive, many companies have downsized and reinvented themselves. Adaptability, flexibility, speed, aggressiveness and innovativeness are the keys to remaining competitive today. Marketing is taking the entrepreneurial lead by finding market segments, untapped needs and new uses for existing products, and by creating new processes for sales, distribution and customer service.
(Occurring within marketing itself) Companies are looking beyond traditional assumptions and they are adopting new frameworks, theories, models and concepts. They are also moving away from the mass market and the preoccupation with the transaction. Relationships, partnerships and alliances are what define marketing today. The cookie-cutter approach is out. Companies are customizing marketing programs to individual accounts.

The Internet has become an integral component of the customer relationship management strategy for business marketers. Dwyer and Tanner (2006) note that business marketers not only use the Internet to improve customer service but also to gain opportunities with distributors.

A standard briefing document

A comprehensive plan to target resources where they will deliver the best return on investment. The infrastructure to support each stage of the marketing process has to be in place and entire organization must be geared up to handle the inquiries appropriately.
Briefing an agency

A standard briefing document is usually a good idea for briefing an agency, as well as focusing the agency on what’s important in the campaign. It serves as a checklist of all the important things to consider as part of the brief. Typical elements to an agency brief are: objectives, target market, target audience, product, campaign description, product positioning, graphical considerations, corporate guidelines, and any other supporting material and distribution.
Measuring results

The value in results measurement is in tying the marketing campaign back to business results. Metrics to measure the impact are e.g. cost per acquisition, cost per lead or tangible changes in customer perception.
Size

Hutt and Speh (2001) note that “business marketers serve the largest market of all; the dollar volume of transactions in the industrial or business market significantly exceeds that of the ultimate consumer market.” For example, they note that companies such as GE, DuPont and IBM spend more than $60 million a day on purchases to support their operations.

Dwyer and Tanner (2006) say the purchases made by companies, government agencies and institutions “account for more than half of the economic activity in industrialized countries such as the United States, Canada and France.”

A 2003 study sponsored by the Business Marketing Association estimated that business-to-business marketers in the United States spend about $85 billion a year to promote their goods and services. The BMA study breaks that spending out as follows (figures are in billions of dollars):

Growth

The tremendous growth and change that business marketing is experiencing is largely due to three “revolutions” occurring around the world today, according to Morris, Pitt and Honeycutt (2001).

Inhalant Effects

Signs and Symptoms of Ecstasy Abuse

Cocaine Effects

Impaired thinking, confused, anxious, depressed, short tempered, panic attacks, suspiciousness, dilated pupils, sleeplessness, loss of appetite, decreased sexual drive, restlessness, irritability, very talkative, scratching, hallucinations, paranoia.

Cocaine Signs/Symptoms
Cravings and Damages:
Help for Cocaine Addicts

Also, get information on crack cocaine use on this page.
LSD (Acid) Effects

Dilated pupils, skin discoloration, loss of coordination, false sense of power, euphoria, distortion of time and space, hallucinations, confusion, paranoia, nausea, vomiting, loss of control, anxiety, panic, helplessness, and self-destructive behavior.

LSD Abuse Signs and Symptoms
LSD Info

PCP Effects

Sometimes violent or bizarre behavior (suicide has often occurred), paranoia, fearfulness, anxiety, aggression, acting withdrawn, skin flushing, sweating, dizziness, total numbness, and impaired perceptions.

Short-term euphoria, giggling, silliness, dizziness, followed by headaches and fainting or unconsciousness. Long-term use: Memory loss, emotional instability, impairment of reasoning, slurred speech, clumsy, staggering gait, eye flutter, tremors, hearing loss, loss of sense of smell, and escalating stages of brain atrophy. Sometimes these serious long-term effects are reversible with body detoxification and nutritional therapy; sometimes the brain damage is irreversible or only partially reversible.
Heroin Effects

Risk taking

If you’re not ready to approach a doctor, help lines or hotlines may be a good place to learn about treatment. You can find these lines listed in the phone book or on the Internet.

Seek emergency help if you or someone you know has taken a drug and:

May have overdosed
Shows changes in consciousness
Has trouble breathing
Has seizures or convulsions
Has signs of a possible heart attack, such as chest pain or pressure
Has any other troublesome physical or psychological reaction to use of the drug

Staging an intervention

People struggling with addiction usually deny they have a problem and are reluctant to seek treatment. An intervention presents a loved one with a structured opportunity to make changes before things get even worse and can motivate someone to seek or accept help.

An intervention should be carefully planned and may be done by family and friends in consultation with a doctor or professional such as a licensed alcohol and drug counselor, or directed by an intervention professional. It involves family and friends and sometimes co-workers, clergy or others who care about a person struggling with addiction.
During the intervention, these people gather together to have a direct, heart-to-heart conversation with the person about the consequences of addiction and ask him or her to accept treatment.
Why people take drugs

There are many reasons why people take drugs. Here are some of the factors which can influence them:

Some people are more drawn to risk taking than others. They may use drugs to fit in with their social group or to help them cope, for a sense of release or individual transformation, or for the thrill.
Predisposition

Hallucinogens

Use of hallucinogens can produce different signs and symptoms, depending on the drug. The most common hallucinogens are lysergic acid diethylamide (LSD) and phencyclidine (PCP).

LSD use may cause:

Hallucinations
Greatly reduced perception of reality, for example, interpreting input from one of your senses as another, such as hearing colors
Impulsive behavior
Rapid shifts in emotions
Permanent mental changes in perception
Rapid heart rate and high blood pressure
Tremors
Flashbacks, a re-experience of the hallucinations — even years later

PCP use may cause:

A feeling of being separated from your body and surroundings
Hallucinations
Problems with coordination and movement
Aggressive, possibly violent behavior
Involuntary eye movements
Lack of pain sensation
Increase in blood pressure and heart rate
Problems with thinking and memory
Problems speaking
Impaired judgment
Intolerance to loud noise
Sometimes seizures or coma

Inhalants

Signs and symptoms of inhalant use vary, depending on the substance. Some commonly inhaled substances include glue, paint thinners, correction fluid, felt tip marker fluid, gasoline, cleaning fluids and household aerosol products. Due to the toxic nature of these substances, users may develop brain damage.

Signs and symptoms of use can include:

Possessing an inhalant substance without a reasonable explanation
Brief euphoria or intoxication
Decreased inhibition
Dizziness
Nausea or vomiting
Involuntary eye movements
Appearing intoxicated with slurred speech, slow movements and poor coordination
Irregular heartbeats
Tremors
Lingering odor of inhalant material
Rash around the nose and mouth

Because GHB and Rohypnol can cause sedation

Meth, cocaine and other stimulants

Stimulants include amphetamines, meth (methamphetamine), cocaine and methylphenidate (Ritalin). They are often used and abused in search of a “high,” or to boost energy, to improve performance at work or school, or to lose weight or control appetite.

Signs and symptoms of recent use can include:

Feeling of exhilaration and excess confidence
Increased alertness
Increased energy and restlessness
Behavior changes or aggression
Rapid or rambling speech
Dilated pupils
Delusions and hallucinations
Irritability or changes in mood
Changes in heart rate and blood pressure
Nausea or vomiting with weight loss
Impaired judgment
Nasal congestion and damage to the mucous membrane of the nose (if snorting drugs)
Insomnia
Paranoia
Depression as the drug wears off

Club drugs

Club drugs are commonly used at clubs, concerts and parties. Examples include Ecstasy or Molly (MDMA), gamma-hydroxybutyric acid (GHB), flunitrazepam (Rohypnol, or roofie) and ketamine. These drugs are not all in the same category, but they share some similar effects and dangers, including long-term harmful effects.

Because GHB and Rohypnol can cause sedation, muscle relaxation, confusion and memory loss, the potential for sexual misconduct or sexual assault is associated with the use of these drugs.

Signs and symptoms of use of club drugs can include:

Hallucinations
Paranoia
Dilated pupils
Chills and sweating
Involuntary shaking (tremors)
Behavior changes
Muscle cramping and teeth clenching
Reduced inhibitions
Heightened or altered sense of sight, sound and taste
Decreased coordination
Poor judgment
Memory problems or loss of memory
Reduced consciousness
Increased or decreased heart rate and blood pressure

Signs and symptoms of recent use can include:

Signs and symptoms of recent use can include:

A sense of euphoria or feeling “high”
A heightened sense of visual, auditory and taste perception
Increased blood pressure and heart rate
Red eyes
Dry mouth
Decreased coordination
Difficulty concentrating or remembering
Increased appetite
Slowed reaction time
Paranoid thinking

Long-term (chronic) use is often associated with:

Decreased mental sharpness
Poor performance at school or at work
Reduced number of friends and interests

Synthetic cannabinoids and substituted cathinones

Two groups of synthetic drugs — synthetic cannabinoids and substituted cathinones — are illegal in most states. The effects of these drugs can be dangerous and unpredictable, as there is no quality control and some ingredients may not be known.

Synthetic cannabinoids, also called “K2” or “Spice,” are sprayed on dried herbs and then smoked, but can be prepared as an herbal tea. Despite manufacturer claims, these are chemical compounds rather than “natural” or harmless products. These drugs can produce a “high” similar to marijuana and have become a popular but dangerous alternative.

A sense of euphoria or feeling “high”
Elevated mood
Relaxation
An altered sense of visual, auditory and taste perception
Extreme anxiety or agitation
Paranoia
Hallucinations
Increased heart rate and blood pressure
Vomiting
Confusion

Viagra could diminish men’s fruitfulness

Taking Viagra could diminish men’s fruitfulness, propose the consequences of another review. The counter feebleness medicate speeds sperm up, analysts found, as well as created the indispensable response expected to enter an egg to happen rashly.

“Viagra was presented in 1998 and from that point forward it has been endorsed to more than 16 million men,” says David Glenn, one of the group that directed the test tube tests at Queen’s University in Belfast, Northern Ireland.

“Most utilize it for feebleness and aren’t considering having a family, so this has no suggestions for them,” he says. Be that as it may, more youthful men are utilizing it recreationally, and they might attempt to begin a family. Moreover, a review of fruitfulness facilities by the group uncovered that 42 for every penny utilize Viagra to help men create sperm tests on request.

Glenn focuses on the work is preparatory yet includes that, if affirmed, would-be fathers and fruitfulness facilities would need to reevaluate their utilization of Viagra.

Plasma level

The group took 45 semen tests from men going to a fruitfulness center and treated half with Viagra and utilized half as a control. They utilized a focus equal to the levels of Viagra found in blood plasma after a man takes a solitary 100 milligram measurements.

Inside 15 minutes, the sperm treated with Viagra began to accelerate, and this went on for 135 minutes. Perceptions following two hours appeared to 79 for every penny more sperm were completely “responded” in the Viagra tests than in the control tests.

This acrosome response is the procedure by which the leader of the sperm discharges stomach related proteins to separate the external shell of an egg, which then permits the sperm to enter and treat the egg.

The new discoveries are upheld by past work by the gathering in mice. Male mice given Viagra and afterward mated with females delivered 40 for each penny less developing lives than those given a control pill. What’s more, in culture, these incipient organisms were additionally less inclined to make due to the five-day blastocyst arrange.

Delegate particles

Glenn disclosed to New Scientist that Viagra triggers the acrosome response ahead of schedule by expanding the development of calcium into the cell, which changes its pH.

Viagra is additionally restrains a chemical called phosphodiesterase that regularly separate envoy atoms required in the vitality procedure. “By restraining the breakdown of vitality, Viagra brings levels of vitality up in the phones,” he clarifies. “This causes the expansion in motility.”

In any case, John Dean, secretary general of the European Society for Sexual Medicine, alerts that lab comes about regularly don’t reflect what really occurs in the body.

He says sperm is exceedingly delicate when expelled from its common habitat. “Childless couples – and the all inclusive community – ought to know that in the five years that Viagra has been around no general hindering impact on ripeness has been watched,” he told the BBC.

Notwithstanding, Glenn is sure his review subjects sperm to similar levels of Viagra they would experience in the body. The group is currently concentrate the impacts of Viagra on the sperm of men really taking the medication. The underlying discoveries in 17 men demonstrate Viagra speeds up sperm.